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When I consider the rider I am, and the rides I want to do more of and want to target, it's long distance solo, overnights, multi-day, mountains. I'm not the fastest rider, and I carry more than I need to, and I'd prefer to feel more faith in the discs than the gingerly rim descents.
So you are talking stuff like Transcontinental, then its fair enough.
IMO build it for Campag EPS hydro as at least thats announced .. if you cant get hold of it by the time its ready go with Sram Etap HRD, you will just have one tiny hole for cable entry somewhere that will be redundant in case of Etap.
142x12 and 100x12 looks like the 'road' standard that should stick mainly because shimano is up for it. DT swiss makes hubs for this standard at 350, 240 and 180 levels.
That is pretty much Cycle Fit's preference for the whole build.
But... distance, mountains and rims.
When I consider the rider I am, and the rides I want to do more of and want to target, it's long distance solo, overnights, multi-day, mountains. I'm not the fastest rider, and I carry more than I need to, and I'd prefer to feel more faith in the discs than the gingerly rim descents.
Mech for the groupset is still a huge win, but disc brakes are also a huge win.
I'm fine fixing on a solution that works today, thru-axle 142/12 looks standard enough that I believe it will survive in some form. I can put Enve 29er rims on Chris King R45 thru-axle disc for a great wheelset, and the thru-axle solves a lot of disc alignment nonsense with QR.
Literally the only icky bit is the Campag levers not yet supporting disc and thus opening a question about which brakes, but there are ways to solve this and in the future there will be products to do this from Campag (but if not SRAM have got me covered).
A predominantly Record groupset save the brakes is ideal.
And if you pore over the Campagnolo website, try and find any compelling reason to go Super Record over Record. That was my first choice, I was looking for an excuse but there is none. The difference is nothing at all, 4g off of a component, but nothing in the performance... the price difference is not worth the 4g.