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True, a cleverly designed course could work - again, more money required.
Relevant Regs:
IAAF Rule 260.28a states: "The start and finish points of a course, measured along a theoretical straight line between them, shall not be further apart than 50% of the race distance."Approved thresholds for marathons are one kilometre per metre drop, therefore a negative elevation of 42.2m is possible.
I'm taking these from an old BBC article, regs might have changed...
Make the whole course on a negative gradient, easy.