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Remember @edscoble saying somewhere on here they're good - also makes sense having a pump on the bike if I'm going to subscribe to Jan Heine's calculus about lower pressures and the benefits. Want to mount it on the non-drive-side seat stay although not sure if it'll be possible with the caliper.
I'm not sure if the SLC is worth the extra money over the standard Spyre, but probably will go that way if I buy 2nd hand as it'll just be a few quid more. Hopefully with compressionless housing it'll be a decent cable disc setup.
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They Zefal HPX are excellent for the money, very light (for the sizes), cheap and work well, it just take a little longer with huge volume tyres.
Standard Spyre will be fine, if they're decent, you should be able to feel it bite sharply, if it doesn't, the mount either need facing or the calipers doesn't allow the pads to sit straightly.
Bear in mind that the old 105 levers have a rather short cable pull, so it'll feel long with the cable pull disc brakes, the latest 105 (and the Tiagra, old and new) have a longer cable pull that work better with disc brakes.
Dont tell @Hulsroy he'll never shut up about how good it is.
Also Spyre or Spyre SLC?