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With semi-hydraulics you only need to wear 1/10 of a millimeter to have the levers bottoming on the bars.
I had a faulty pair of HyRD that did not compensate and I ran out of brakes during Gent-Wevelgem, which is essentially flat... but it was very muddy and wet. Had to stop and botched a repaired by manually pulling the arm to get the pads closer.
They were since replaced by HyRD with working ones
Possibly. This is my commuting bike, so not an issue... if it was a CX bike for racing, I wouldn't want to have to get off and adjust the pads in a race.
On balance the ability to adjust the lever throw is more of a feature than self adjusting will ever be.
However, metal piston and no reservoir means I would not use them to descend Monte Zoncolan, whereas I have come down some pretty vicious descents with the HyRD