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I really enjoyed fallout 4.
Just try to focus on a few things not being a master of everything. Flying things are annoying but focus on vats or sneak. Sneaking will give you a 2x damage bonus.
Also always have a follower - they will 9 times out of 10 soak up the damage for you.
My first and only gameplay (just finished) was mainly around pistols and sniper rifles.
The playthrough I have just started I am aiming to be melee only so far I have a tire iron and a lot of balls charging into a big group. The first big hurdle will be trying to fight off a deathclaw. On second thoughts I might have to avoid them for a while.
Fallout 4? I'm about to give it another go... never really got in to it, any tips? I think I got bored wandering around with a shit gun then getting destroyed by 3 big flying bug things or a horde of those zombie things.