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Well...yes and no. Sometimes the will of constituents is seen as an excuse to be an asshat (hi, NI...)
But in this case there are good arguments to be made to get much more detail. Brexit is brexit means nothing. Walking blind into something cos "the people voted x" isn't good democracy esp. not with so much at stake.
So in this case saying "hey my constituents are against it, there are massive risks for everyone, I won't vote on this until you clarify it/cut the xenophobic crap/address other issues/I have more info its a clusterfuck so no" is more than fair enough.
Cambridge's MP is all like "Fuck off. My constituents didn't want to leave, I don't want to leave, so bollocks am I supporting leaving in any way".
Fair enough? He was elected to represent his constituents, not the country as a whole and 74% of them voted remain.