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Well...yes and no. Sometimes the will of constituents is seen as an excuse to be an asshat (hi, NI...)
But in this case there are good arguments to be made to get much more detail. Brexit is brexit means nothing. Walking blind into something cos "the people voted x" isn't good democracy esp. not with so much at stake.
So in this case saying "hey my constituents are against it, there are massive risks for everyone, I won't vote on this until you clarify it/cut the xenophobic crap/address other issues/I have more info its a clusterfuck so no" is more than fair enough.
http://www.bbc.co.uk/news/uk-politics-37944473
Some politicians finally saying they won't vote for Brexit unless there's more clarity than "out = out, breakfast means breakfast" to protect constituents interests/cos Scotland/cos their area voted out.
Disappointed that Labour isn't giving a stronger message of "yeah we accept the out vote BUT if you try to take workers rights, or EU national rights it ain't gonna happen".