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It kind of depends. I went up to 700x38 on my pomp, and they were great but it kind of felt like the wheels were getting TOO big. In that case 650x38 would have been the same sort of squish but the acceleration and handling would have been better. In the same vein, my 26x54 Compass tyres feel better than the 700x38 Challenge tyres, as the rims and tyres are pretty much the same weight.
So basically, as I understand it you can switch to 650 to reduce weight and size, or to keep the same weight and size while increasing squish
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If the bike come with 700c and big tyres, there is little point in changing.
However, one of the other main advantage of 650b is being able to run MTB tyres, a good example is the Specialized Sequoia that run 700x42mm currently, but with 650b, 2.0 tyres will fit, maybe bigger.
I have my bike build to take 700c x 38mm tyres, 650b x 2.1 tyres or 26" 2.2 tyres simply by providing ample chainstay clearance.
Sorry, I may get blasted for posting this on the 650 thread, but even though I love spending money on new unnecessary bicycle related stuff, I could never come to peace with the idea of converting, let's say, my AWOL to 650. Why? I currently run folding bead 35mm wide paselas (not radavist-favorite, sorry) on wide AWOL standard rims, and this setup is as plush as one would want. Why switch to, let's say, wtb horizons that weight at least 100 grams more than my current tires, with probably same outer wheel diameter? Am I going to save that much weight on rim and spoke length?