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Up from where? Enough to make it a viable business against rising East London rents?
I was responding to your point that it was likely due to new methods of consumption rather than a collapse of the pound due to Brexit. I.e.:
I suspect that the digitisation of print and the changing consumption models has more to do with it than pure Brexit.
If your point was about renting costs in London, I happily concur that this likely makes it tough for any independent shop.
I'm not a comic book nerd, and subscriptions to digitized comics is a thing, but hard copy sales have gone up in recent years.