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NY Times suggested his non sequiteurs might be a 'flight of ideas'.
Manics display something called “flight of ideas.” It’s a formal thought disorder in which ideas tumble forth through a disordered chain of associations. One word sparks another, which sparks another, and they’re off to the races. As one trained psychiatrist said to me, compare Donald Trump’s speaking patterns to a Robin Williams monologue, but with insults instead of jokes.
He also appeared to have a bit of a Colombian cold.
Or he just had a regular cold and combined with his strange non sequiturs, it just gave the impression of one.