Such disc many aeros
https://www.cervelo.com/en/road/s-series/s3-disc
...and 23mm tyres as standard. Doesn't look like they've even made room for anything bigger with legal clearance. I suppose if your dental practice is doing well you can get an R3d for days when you want 25s and a C3 for rides requiring 28s :)
@gbj_tester started
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Such disc many aeros
https://www.cervelo.com/en/road/s-series/s3-disc