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Ah cool, I've just got back today from my trip covering very similar territory to @KT_Bee. Me and MsPub flew to Vancouver, then buses through Seattle and Portland, then to Tillamook where we started riding properly, just under 800 miles to San Francisco in 13 days (incl. one rest day). We were on a schedule to get overnight train and bus back to Vancouver after a couple of sightseeing days in SF, but happy to report that saddle sore was the worst of our problems, longest day was just over 90 miles and the Pacific Coast Highway is HILLY.
Echoing comments above, some of the bridges were a bit sketchy, and we were probably lucky with most logging trucks seeming to be going the other way, but generally found the whole route and people very bike-friendly.
Just heading home after nearly 4 weeks touring down the Pacific North West from Seattle to San Francisco. No tales of epic heroism - I kept the daily mileage pretty modest so I had time to explore / hang out.
Oregon was great start to finish. Washington was beautiful but maybe not so cycle friendly. Northern California was just foggy.
Couple of things I discovered along the way:
If you're as fearful as me, swallow your pride and hitch a lift across the Columbia from WA to Astoria. I didn't and came as close to death over the 4 1/2 mile bridge with no shoulder, side winds and logging lorries, as I ever have.
I couldn't face the ride into Portland and discovered that little local buses go there from Tillamook on the coast. Pretty infrequent, but you can put your bike on the front.