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There was a young chap on our ride through Italy two years ago. It turned out he had only once ridden more than 100 miles in a day before. Never really done any long rides. He was young and fit and quite fast. He had heard people talking about chamois creme but never really paid attention.
After three days he was sore. On the fourth day, it was agony to pull on his shorts and so he had a bright idea and popped some underpants underneath his shorts.
He was removed from his bike, his shorts and his underpants after a couple of hours.
The physio was horrified by what she saw. A raw and bloody mess.
She worked her magic. He somehow avoided an infection. He was back on the bike after a day and a half of recovery and even managed to get married a few months later.
:thumbsup
Actually lolled when I read his latest tweet.