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I was worried, a lot, while building the bike, even more when the Kinesis 4S Disc frameset that was announced to be 160 compatible at the rear... came out to be a lie / design fail... But even with mech calipers its ok, haven't crashed yet :D. I use TRP normal discs, but got a 140 + 160mm rotors with dissipation for free and tried them with nice results http://www.reverse-components.com/en/products/discrotor-aircon-%C3%B8140mm
16,64stones here (had to google it to be able to understand how many stones you need to express 106kg of weight). And going down 10-15% descents, (and up) with a ~90kg rider + 16kg of bike and equipment. Front 160 for sure, but back... 140 is more than enough (with mech disc brakes), even under snow and wet conditions north-alike... but technique is also important. In the pictures, there is no water (2liters ~ 2kgs) or food in the bike... shoes and helmet count too