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What @kl said.
If you do hit the canal East from Picadilly would take you towards Velodrome with trails in Clayton Vale.
Else head to Old Trafford from Deansgate Locks.
Both runs would be out n back and avoid the drug/pickup spots.
There's nice running along Mersey Valley near Sale Waterpark but you'd do your 10k just getting out there and back.
rhb
Lebowski
Cheers. Last time I walked down the canal in Manchester I went under a bridge and stumbled upon a what was either a drug deal, gay pick up point or I must have been seconds away from being killed and dumped in the river. Hopefully 6am in the morning things will be a bit quieter.