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What @kl said.
If you do hit the canal East from Picadilly would take you towards Velodrome with trails in Clayton Vale.
Else head to Old Trafford from Deansgate Locks.
Both runs would be out n back and avoid the drug/pickup spots.
There's nice running along Mersey Valley near Sale Waterpark but you'd do your 10k just getting out there and back.
I've never found anywhere particularly good in the centre of Manc - just run up and down the canal.