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Wading in with my size 12's here...
I had my saddle in a neutral position as far as the scale on the rails goes. Slammed it forward 15mm and immediately noticed a difference in power transfer through the pedals. I can now push on them - and my knee is above the pedal spindle at the 3 o'clock position. Previously it felt just like I was spinning the crank and a distinct lack of power and was a few cm behind the spindle. I think my Cannondale post has 2.5cm setback. Perhaps I could do with an inline? Should probably just pony up for a proper bike fit but have been messing around myself with fit for now.
I have a question. All else being equal, will bigger feet mean the saddle will need to be further forward, or further backward?