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Dirt wizards on 50mm rims are 76.5 at their widest, about 345 from the axle.
Bottom gear on a 10s cassette on a 135m axle should be about 25mm off centre.
Add 6mm clearance and 3mm for half a chain width, the chain needs to be 47mm off centre at the tyre, so 51mm chainline and a shorter chainstay will give you better tyre clearance.
As the rear mech pulleys move in the same plane as the sprockets, the shorter your chain is the worst tyre clearance will get.
Emyr
Ah, 135 would work, curious to see if there's clearance in the 1x1 without running the wheel all the way back