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You can test the leg rubbing also, I did a simple test with bubble wrap around seat tube and headtube and around again, with some tape to keep it in place while on the indoor trainer.
Looking at the geometry chart, you'll loose 1,5cm of height and 1,3cm of lenght, but if you use some 750ml bottles instead of 1L you may get even more space since Camelbak 710ml bottles are 4,5cm shorter than 1L SIS ones. Anyway any storage space gained will be great to remove heavy objects (spares, phone, battery...) from the seatbag to avoid some wobbling when out of the saddle or in hairpin corners.
I just left enough room for the bottles to be open without touching the bag, no mental adaptation required to get them in/out even going full gas in the 9th hour to make the 10h objective.
Talking more about framebags... I was intrigued what could I store inside a rear triangle framebag like the one shown here between the seat stays and the seat tube... since my frame is so big, theres a nice space there. About the same size as a fuel pod but with a piramidal shape.
Yeah, I've got the 57cm version so I lose a lot of triangle real estate compared to you.
I guess it's still an option for me but I'll need to build it up and have a look at how much room I have with bottles and knees and stuff before I proceed with a bag.
I used a Deuter frame bag during PBP which worked "ok", save for it not being secured at the bottom so it flicked left to right all the time.
Actually, I have the normal Kinesis 4S sitting at home without a rear wheel at the moment - I should just put that back together and test fit bottles to see how much room I have!