What have you got going on? All radiators off - valves closed only, system filled, maybe you'll get away with all the valves working especially if it's a new install. I wouldn't run the boiler with the system empty - you could switch off the CH heating side, i.e. thermostat control CH OFF and that should save it from trying to heat water that's not there.
It's a slightly unusual situation for me as usually the system is filled before you switch the boiler on.
What have you got going on? All radiators off - valves closed only, system filled, maybe you'll get away with all the valves working especially if it's a new install. I wouldn't run the boiler with the system empty - you could switch off the CH heating side, i.e. thermostat control CH OFF and that should save it from trying to heat water that's not there.
It's a slightly unusual situation for me as usually the system is filled before you switch the boiler on.