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Once a week should be doable?
I've variously heard about people doing those sorts of commutes. Back in the day when the London Cyclist had a feature called 'My way' (meaning commute), I tried to track down someone who allegedly rode to Great Ormond Street Hospital every morning from Waltham Abbey. I never managed to find him, but the person who started the rumour was adamant it was true.
I think whether or not it's sustainable as a regular commute depends very much on what sort of environment you have to go through, e.g. constant urban stop-and-start would be pretty wearing. Rural roads would be easier, though. I used to ride to Chelmsford quite often to visit a friend, and I think that was about 35 miles. There and back once a week I'd find perfectly sustainable.
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to Great Ormond Street Hospital every morning from Waltham Abbey.
Sounds not too dissimilar to @rhowe 's commute.
Apart from the origin and destination of course.
How far is too far for a daily commute?
That is the question. Added to the physical nature of the work, I'm thinking a 27mile each way slog may be relegated to occasional fun.