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People used to claim the 320tpi Vittoria's where less prone to punctures because as they where supple they deformed around any nasty objects in the road.
By that logic the Vittoria Pista Evo CS must be the totally reliable :-)
I don't want to start on a rant about the marketing of TPI-- kind of like clock rate in CPUs but with the added twist that some vendors count each layer-- but higher thread count does not lead to higher defense against sharp objects like glass. The point of high TPI is, in concept, to allow for thinner, lighter casings and to reduce the tread contact patch, whence reduce rolling resistance and improve "ride feeling". High TPI tyres are, however, more rather than less prone to fault. To get around this vendors tweak the rubber mix (adding nano carbon or graphene) and add special breakers under the thread.
Where "flexibilty" does indeed lead to lower fault rates is with the inner-tube. A thick latex inner-tube weighs around the same as a thin butyl but has a distinct edge in fault resistance-- latex has, however, a number of issues that make the decision not as clear cut as this statement might make things appear.
Has this actually been tested anywhere ?
People used to claim the 320tpi Vittoria's where less prone to punctures because as they where supple they deformed around any nasty objects in the road. In my experience they're the most puncture prone tyres I have owned
Anecdotally the rubber compound, the amount of rubber and the puncture protection strip make far more of a difference.