The issues i can think of are chainline + possible wrong forces on the spokes?
The spokes are fine, when you flip the wheel round the spokes which were the pulling spokes for your brake retarding the bike are still the pulling spokes for your sprocket accelerating the bike.
Chainline on a135mm ISO rear hub should be about 53.85mm with a ⅛" sprocket, that should be pretty much spot on for the outer ring of a 2× MTB chainset, but quite a bit too wide to work well with a road chainset.
The spokes are fine, when you flip the wheel round the spokes which were the pulling spokes for your brake retarding the bike are still the pulling spokes for your sprocket accelerating the bike.
Chainline on a135mm ISO rear hub should be about 53.85mm with a ⅛" sprocket, that should be pretty much spot on for the outer ring of a 2× MTB chainset, but quite a bit too wide to work well with a road chainset.