If you can, go for it, otherwise HY/RD is enough.
Would I be able to tell the difference between the stock 440g tyres and a pair of 350g Continentals?
Yep
On the CdF? the tread on the stock tyres is more all-round for road and towpath, so going for a slick one will make it feel slightly more nimble, like the Schwable Kojak at 295g.
@Crispin_Glover started
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If you can, go for it, otherwise HY/RD is enough.