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100% agree with amey.
Putney <--> Canary Wharf is my commute. I used to stay sarf to Southwark Bridge, but fuck that. Fuck Vauxhall roundabout, Waterloo roundabout and the road leading to it, Southwark high street, and especially Battersea high street. No thanks.
Putney bridge (or Wandsworth if you're east side massif) --> New King's Road --> follow river to Blackfriars. Fewer punctures, traffic lights and high street nastiness - choose a sprint along CS8.
Rumour has it my office is moving from the West End to Liverpool Street. What's a stress free route from Putney to Liverpool Street area? The few times I've done it have been via Riverbank - > Chelsea Bridge - > Embankment -> Traf Square and Strand - > St Paul's and Cannon Street - > Up Bishopgate
I assume that's not the best route, seems to involve lots of traffic and messing about in the city where the constant roadworks/closures and resultant traffic jams are a nightmare...