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My wife and I managed it, though it needed both of us. One to hold cat and head while the other opens the eye and applies drops. Used the technique of wrapping cat in blanket or towel with only head poking out, to prevent escape and scratches. Ours were only kittens when we had to do this, wouldn’t fancy trying now they are adults.
Helps if you see your vet do it first. The way they handle the cat was an eye opener for us. More assertive than we were used to.
Has anyone ever successfully put eye drops in a cat's eye?