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I work by moorgate and Running around the city at lunchtime is about as appealing to me as trying to get on the central line with a full set of luggage at 5.30pm. it's bad enough walking around here.
When my runs call for enough distance that I can run at least 1/2 the distance home I'll go back to my old ways of running to balham after work and getting tube home from there where it's nice and quiet the rest of the way. and slowly finish one stop further from work as my mileage goes up.
I often go to my gym and just use the shower/ changing facilities to go for a run. I really can't deal with people seeing me run indoors. Also I find the outdoors just too tempting.