In the sense of not being anything like them?
New Vegas is Fallout 3 set in Nevada, with a cool storyline, and rather more emphasis on the choices you make. I played it before F3 and loved it.
Are you talking background or gameplay? obviously the latters is completely different.
Gameplay :-)
I got Fallout 1 & 2 (and Fallout Tactics) for free off Gog.com a while ago. The gameplay is so bad it's a wonder they led to Fallout 3. The story and iconography is cool though.
@edscoble started
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In the sense of not being anything like them?
New Vegas is Fallout 3 set in Nevada, with a cool storyline, and rather more emphasis on the choices you make. I played it before F3 and loved it.