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There was a research paper that showed they work if the oval is larger than 1.5 :1 and at the right spot, I'll try to find a link.
edit: found it.
http://www.noncircularchainring.be/pdf/Biomechanical%20study%20chainrings%20-%20release%202.pdf
But.. Its only a mathematical model. no testing. so maybe dubious results
Biopace, oval chainrings before they figured out how they work