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If you look at how most are put together it's just the bottom(?) tube that's different from normal bikes.
Depends where you look, but there are tandem tubesets and there is the option to use the beefiest solo tubes for the ones which are the same as solo frames. Also a pretty large range of possibilities in plain gauge 4130. I'd want the pilots downtube to be pretty stiff, as that combined with the drainpipe is the backbone of the chassis.
If you look at how most are put together it's just the bottom(?) tube that's different from normal bikes.