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Thanks to you both @BareNecessities @AdsH, I've never had a proper bike fit so I'm very shaky with measurements as all my bikes are varying sizes. I'm most comfortable on my 57 (550 effective) CX bike with a 100mm stem, which I think is better suited to my longer legs and shorter torso.
I suppose I could always use the stem to stretch out on a smaller frame, if I found it too cramped. Does the more upright position mean being cramped up is less of an issue?
You have to look at the specific geo to make an informed decision or face an expensive mistake. The 2 most important measures are effective top tube and reach.
Not knowing knowing if you are a gibbon or leggy doesn't help but the effective top tube on the 21.5 is mahoosive and very unlikely to fit you with a normal 70mm - 80mm stem. I ride a 627mm ETT with an 80mm stem at 6' (and that's probably a bit longer than normal) so you are unlikely to want to go above the 19.5" which has an ETT of 639 and will probably allow you to run a normal stem and bars.
Reach looks long too at 443 for the the 19.5" so the 21.5 must be designed for giants
ps looks a nice bike