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Hovis
I think you are barking at the wrong tree. Your spoke didn't fail because of the enforced bend... fatigue lines are not something you necessarily see by naked eye on a 2 mm section of steel... but fatigue it was... any failure which is not due to excessive stress is fatigue. Folks have been lacing 24 H 2 cross for decades without any issue. I suspect your wheel has too low tension, which is the cause of spoke failure 90% of the times.
If you don't interlace, you lose a significant amount of stiffness... I have tried once for curiosity and the wheel was literally made of cheese. Factory wheels get away with that by hub design (it's my guess).