Which Groupset?

Ed's right. The best thing is to go and try a selection of groupsets and choose the one that you like the shifters on. They all work well, are durable, etc., so it comes down to personal preference.

Exactly right. If everyone did this, then SRAM Red would not exist.

That said, to me the best-feeling shifters are Campag EPS, and I've seen them fail on group rides more than once.