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umop3pisdn-
Potentially, I mean you wouldn't want to be doing it every weekend with all the cabling etc (although you could design it to be minimum hassle) but I don't think a functional multi application frame is impossible. Swap out dropouts and spare forks mean you could have a fair degree of adjustability on the geo and the capability for racks/guards etc
Would be an interesting project. Expensive though. I had been day dreaming about an alternative setup for my Argos, 1x6 for instance with a DT shifter, not necessary at the moment but potentially in the future.
TM
Or switch back wheel around and use bolt on..
I think it's doable definitely and could work without being such a compromise.