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@Angus
I've had maybe a few months without much riding but managed to get out a bit over Christmas. First ride was 60 miles and the top of my knees gave me some serious trouble for the next two days. The last three or four rides have been shorter as I'm worried about aggravating my knees again. I was regularly doing longer distances over summer with no knee issues.
The only thing that has changed with my set-up is that I've been wearing tights lately. Could the pressure from the tights really be causing an issue?