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I'd say it was worth it.
The Shard was just opening when we moved to Hither Green (one stop from London Bridge in peak times), and since it's opening, house prices have risen over 30% in two years. I would say that Crossrail should beat that level of inflation with ease but you wouldn't see a lot of that until around 2020.
What that will mean though is you should be at the end of a 5 year fixed term (if you can get one) and remortgaging will see a dramatic change in your LTV %.
The Crossrail is definitely a consideration. We see this as the first step on the ladder. So if making a sacrifice on location for a few years is needed then I guess its what we're gonna have to do. The flat is great, even more so when you compare it to similar priced properties in the places we've currently been looking (Plaistow, Upton Park).