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Ed has suggested something with discs. Do you want discs? They seem to be everywhere and on everything at the moment. I'm in a similar position to you, and am pondering a new purchase. I keep getting tempted by discs, but also keep reminding myself that rim brakes have been just fine for an awfully long time. A good dual pivot mid trop brake like the TRP RG957 has plenty of clearance for a decent size tyre and mudguard and will most likely meet all braking requirements. I keep looking at the Kinesis Gf Ti V2 on some good deals online and wonder whether snapping one up would be a good idea. The other thing is that the bloke from Kinesis is going it alone and starting his own brand which will apparently be some similarly practical but stylish stuff with disc brakes.
This is what concerns me, the thought of going into some hip custom framebuilder's workshop, plonking down a deposit, and saying "make me, uh, a sort of low-end Trek Madone"