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No clue, I've believed marketing bullshit (and one or two tests) on this one, also got to think about less rolling resistance; but say: new zipps, a speedsuit and an aero helmet (they're starting to look better) would be a better investment I reckon.
Above all else I'd feel like a top bellend going on a casual ride with an aero frame like a Propel, they look cool as fuck with pro's on them, don't get me wrong, but if you're slogging your way up the local slopes getting passed by guys with actual fitness on normal looking bikes, the gains count for fuck all
Most the time though, more benefits can be had elsewhere, for example rather than buy a new frame, get rid of old zipp 40mm V's and get some firecrests, or better lycra etc. GCN did a good little review/comparison thing