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London Marathon usually has one or two peeps keel over. To be expected with the large numbers and physical exertion.
"The overall mortality rate from the 20 years is one in 67,414, or roughly one death for every two million miles run." Source: http://www.pponline.co.uk/encyc/london-marathon-what-we-know-about-the-incidence-of-injury-illness-and-death-in-the-london-marathon-881
I read somewhere (trans: I can't find the reference) that the majority of post-mortems of London Marathon fatalities show congenital heart defects that simply had never been diagnosed (mainly because there was no reason to go looking for them).
If you're young (14-35) and want to get checked out then try: http://www.c-r-y.org.uk/ for a screening (I had one about 4 or 5 years ago - and got the all clear - as Mrs GB was worried about the amount of long distance riding I was doing).
Holy shit - just read on BBC news ticker that someone died of heart failure on this!
http://www.bbc.co.uk/news/uk-england-28742179
That is really, really sad.