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Atleast if you're gonna build bike with disc brakes, you're basically gonna have to go 10-speed because there ain't much 11-speed disc hubs available. (Those few that are, are damn expensive).
makko-
You're right, and I am planning on disc brakes. However, I did find one from Novatec that isn't too expensive. Might not be great value though, I'm not sure.
http://www.bdopcycling.com/Hubs-D352SB-11.aspIt's a bit annoying that there ain't more to choose from. Especially now with the 105 coming out with such a great pricing.
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Kinesis Crosslight disc wheels are 11sp compatible and a light wheelset for £270 seems pretty good:
http://www.kinesisbikes.co.uk/products/wheels/crosslight-cxdisc
detsamma
Joe.S
48t or 46t up front would, as you say, probably better. Like many others I'm really liking the new Shimano 105 which would be the reason for the 50t up front. As I understand it it's rather difficult to find a 48t or 46t for that chainset? Would I be better of going with a 10 speed group instead?